论文部分内容阅读
目的观察隔日应用盐酸帕洛诺司琼预防化疗致胃肠道反应的临床疗效和安全性。方法首次接受含大剂量顺铂方案化疗患者72例,随机分为观察组和对照组各36例,观察组化疗同时隔日应用盐酸帕洛诺司琼,对照组每日同时应用盐酸托烷司琼;观察2组化疗第1~5天食欲减退、恶心、呕吐控制情况及化疗期间不良反应,并进行比较。结果 2组化疗第1~5天食欲减退控制率比较差异无统计学意义(P>0.05);观察组化疗第3天恶心控制率(77.8%)高于对照组(55.6%)(P<0.05),迟发性呕吐控制率(80.6%)高于对照组(58.3%)(P<0.05)。结论隔日应用盐酸帕洛诺司琼可有效预防化疗所致急性和迟发性胃肠道反应。
Objective To observe the clinical efficacy and safety of palonosetron hydrochloride on preventing gastrointestinal reactions induced by chemotherapy every other day. Methods 72 patients with high-dose cisplatin regimen were randomly divided into observation group and control group with 36 cases in each group. Palonosetron hydrochloride was used in the observation group as well as every other day while the control group was treated with tropisetron hydrochloride ; Observed 2 to 5 days after the first two days of anorexia, nausea, vomiting and adverse reactions during chemotherapy, and compared. Results There was no significant difference in the rate of loss of appetite control between the first and fifth day after chemotherapy (P> 0.05). The rate of nausea control (77.8%) in the observation group on the third day was higher than that of the control group (55.6%) (P <0.05) ), And the control rate of delayed emesis (80.6%) was higher than that of the control group (58.3%) (P <0.05). Conclusion The application of palonosetron hydrochloride every other day can effectively prevent the acute and delayed gastrointestinal reactions induced by chemotherapy.