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目的探讨经皮冠状动脉介入(percutaneous coronary intervention ,PCI)治疗急性心肌梗死的疗效及对血同型半胱氨酸(homocysteine ,Hcy)、缺血修饰蛋白(ischemia-modified albumin ,IMA)、超敏C反应蛋白(hypersen?sitive C-reactive protein ,hs-CRP)的影响.方法选取2018年1月—2019年2月在北京市大兴区中西医结合医院治疗的急性心肌梗死患者198例,均行急诊PCI治疗,观察治疗疗效,比较治愈患者与非治愈患者临床资料、Hcy、IMA及hs-CRP水平.结果198例患者中,经急诊PCI治疗后,66.67%的患者治愈,26.77%的患者有效, 6.57%的患者无效;治愈组左心室射血分数(left ventricular ejection fraction ,LVEF)为(50.04±8.27)%,明显高于非治愈组(45.59±7.18)%(P＜0.05),而Gensini评分为(30.82±8.11)分,明显低于(38.89±6.21)分(P＜0.05);治愈组术后24 h患者Hcy、IMA和hs-CRP分别为(34.48±8.03)mol/L、(102.19±28.89)U/L和(13.22±2.78)g/L,明显低于非治愈组(P＜0.05).结论 PCI治疗心肌梗有较好的疗效,治疗后患者Hcy、IMA、hs-CRP明显升高,相较于非治愈患者,治愈患者升高幅度有所减轻.“,”Objective To investigate the effect of percutaneous coronary intervention (PCI) on acute myocardial infarc?tion (AMI) and the changes on blood homocysteine (Hcy), ischemia-modified albumin (IMA) and hypersensitive C-re?active protein (hs-CRP). Methods A total of 198 patients with AMI who admitted to the department of cardiology of Beijing Daxing District Hospital from January 2018 to February 2019 were selected to this study. All patients experi?enced emergency PCI treatment. The effect of PCI was observed. The levels of Hcy, IMA and hs-CRP were tested and compared between PCI-cured and PCI-non-cured patients. Results 132 patients (66.67%) were cured after emergency PCI. 68 patients were non-cured which included 53 patients (26.77%) who were effective and 13 patients (6.57%) who were ineffective. The left ventricular ejection fraction (LVEF) of the PCI-cured group was (50.04±8.27) %, which was significantly higher than that of PCI- non-cured group (45.59±7.18)% (P < 0.05), Gensini score was (30.82 ±8.11), which was significantly lower than that of PCI-non-cured group (38.89±6.21) (p<0.05).. The levels of Hcy, IMA and hs-CRP in PCI-cured group at 24 hours after treatment were (34.48±8.03) mmol/L, (102.19±28.89) U/L and (13.22± 2.78) g/L, which were significantly lower than those of PCI-non-cured group (P<0.05). Conclusion PCI has a good ef?fective treatment for AMI. The levels of Hcy, IMA and hs-CRP in patients with PCI treatment increase significantly. The changes of those levels in PCI-cured patients are dramatically reduced as compared with non-cured patients.