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心房颤动(简称房颤)的药物治疗策略包括节律控制和心率控制。节律控制的药物治疗包括离子通道阻滞剂、基质治疗、连接蛋白、细胞内钙稳态和基因治疗等。Ⅰ、Ⅲ类离子通道阻滞剂是目前应用转复和维持窦性心律的常用药物,但长期有效性欠佳;血管紧张素转换酶抑制剂或受体阻滞剂,他汀类等对房颤发生基质有改善作用,可降低房颤的发生,但对房颤本身无治疗作用,其他方面的药物治疗尚处于研究之中。
Pharmacologic strategies for atrial fibrillation (atrial fibrillation) include rhythm control and heart rate control. Rhythm-controlled drug therapy includes ion channel blockers, matrix therapy, connexins, intracellular calcium homeostasis and gene therapy. Class I and III ion channel blockers are commonly used drugs for the recovery and maintenance of sinus rhythm, but their long-term ineffectiveness is poor. Angiotensin-converting enzyme inhibitors or receptor blockers, statins, Occurrence of matrix to improve the role, can reduce the occurrence of atrial fibrillation, but no treatment of atrial fibrillation itself, other aspects of drug treatment is still under study.