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目的:了解颐生母液对小鼠低氧游泳耐力和某些生理指标的影响。方法:在青海海晏县(海拔3 100m)进行小鼠低氧游泳耐力实验,将70只小鼠随机分为颐生母液高、中、低三种剂量组(分别灌服5g/kg、3.5g/kg和2.5g/kg)、阳性对照组(灌服红参水煎液)和空白对照组(灌服等体积蒸馏水),连续灌服10天。第11天进行游泳试验,观察记录游泳至死时间,并称小鼠体重和脾脏、胸腺重量,计算相关脏器指数。结果:颐生母液三种剂量组及红参组(阳性对照组)均能提高小鼠的低氧游泳耐力,游泳时间明显延长(P<0.05或P<0.01);而且胸腺指数、脾脏指数均高于对照组(P<0.05)。结论:颐生母液能明显减轻高原低氧环境对小鼠体能的影响,具有提高机体低氧耐力、免疫功能和抗疲劳的作用。
Objective: To understand the effect of Yisheng mother liquor on hypoxia swimming endurance and some physiological indexes in mice. Methods: Hypoxic swimming endurance test in mice was conducted in Haiyan County, Qinghai Province (3 100m above sea level). Seventy mice were randomly divided into high, middle and low doses of Yisheng mother liquor (5g / kg, 3.5 g / kg and 2.5g / kg), the positive control group (ginseng with red ginseng decoction) and blank control group (fed with equal volume of distilled water) for 10 consecutive days. On the 11th day, the swimming test was carried out, the swimming time to death was observed and recorded, and the body weight, spleen and thymus weight of mice were weighed and the relevant organ index was calculated. Results: The three doses of Yi-sheng mother liquor and the red ginseng group (positive control group) all increased hypoxia swimming endurance and prolonged the swimming time (P <0.05 or P <0.01), and the thymus index and spleen index Higher than the control group (P <0.05). Conclusion: Yisheng mother liquor can significantly reduce the impact of plateau hypoxic environment on mice physical ability, improve the body hypoxia tolerance, immune function and anti-fatigue effect.