动脉粥样硬化时动脉平滑肌细胞增殖及表型转变的若干分子调控机制

• 作 者: 杨小毅 杨永宗
• 机 构: 衡阳医学院心血管病研究所,衡阳医学院心血管病研究所,
• 出 处: 衡阳医学院学报
• 发表日期: 1991年03期
• 关键词: 平滑肌细胞增殖 合成型 粥样斑块 细胞生长 细胞外基质 收缩型 生长因子 分子调控机制 内皮细胞 细胞因子

动脉粥样硬化(Atherosclerosis,AS)是一种以细胞增生为主要病变的疾病,近年来,众多的研究表明动脉平滑肌细胞(Smooth muscle cell,SMC)是动脉粥样斑块中最主要的细胞成份,并且动脉平滑肌细胞至少有两种细胞表型,即“合成型”(Syn-thetic Phenotype)和“收缩型”(ContractilePhenotype)。在一定因素刺激下,细胞发生分化增殖,表型发生改变,分泌大量细胞外基质,可以引起细胞内外脂质沉积,形成动

Atherosclerosis (AS) is a kind of disease with cell proliferation as the main lesion. In recent years, numerous studies have shown that the smooth muscle cell (SMC) is the most important cell component in atherosclerotic plaque , And arterial smooth muscle cells have at least two cell phenotypes, namely “Syn-thetic Phenotype” and “Contractile Phenotype”. Under the stimulation of certain factors, the cells undergo differentiation and proliferation, change their phenotypes, and secrete a large amount of extracellular matrix, which can cause lipid deposition inside and outside the cells and form a dynamic