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本文研究5例肌萎缩侧索硬化患者,用部分提纯的大剂量人体白细胞干扰素治疗的药物反应。年龄46～65岁;男3,女2。治疗计划是头2天用1亿1u/日,以后4天2亿iu/日,连续静输。此后2个月,用3百万iu/日肌注。但实际上由于出现了疲乏,GOT及GPT上升,白细胞减少等副作用,仅1例肌注过6百万iu,而静输累积总剂量为每例250×106iu～950×106iu。用多种神经心理试验观察干扰素的药物反应。(1)用Wechsler成人智能检查(WAIS)亚试验[知识、相似物(语言智商)、作图(操作智商)]作观察,在治疗前及后第20天实施,未见变化。(2)用Wechsler记忆检查(WMS)亚试验(定向力Ⅰ,Ⅱ,精神控
This article studies 5 patients with amyotrophic lateral sclerosis, with a partially purified high-dose human leukocyte interferon-treated drug response. Age 46 to 65 years old; male 3, female 2. Treatment plan is the first 2 days with 100 million 1u / day, 4 days after 200 million iu / day, continuous quiet lose. After 2 months, with 3 million iu / day intramuscular injection. In fact, only 1 case of intramuscular injection exceeded 6 million iu due to fatigue, increased GOT and GPT, and decreased side effects such as leukopenia, while the total cumulative dose of intravenous infusion was 250 × 10 6 to 950 × 10 6 iu. A variety of neuropsychological tests to observe the interferon drug response. (1) Observed by the WAIS sub-test [Knowledge, Similarities (IQ), Mapping (IQ)] Wechsler Adult Intelligent Examination (WAIS) was performed on the 20th day before and after treatment with no change. (2) Wechsler memory test (WMS) sub-test (orientation force Ⅰ, Ⅱ, mental control