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本文应用G显带和C显带染色体分析的方法,对人体肺腺癌细胞系LGC-7910的第150、173及183三代细胞进行了系统的细胞遗传学研究。发现本细胞系染色体众数为67至69,具有许多涉及复杂染色体重排的标记染色体。其中9号染色体长臂的等臂染色体可能是肺腺癌的特征性畸变。9号染色体在大部分细胞中丢失,9号染色体短臂丢失可能在肺腺癌的生存及演进过程中起一定作用。
In this study, the G-banding and C-banding chromosome analysis of human lung adenocarcinoma cell line LGC-7910 150,173 and 183 third generation cells were systematically cytogenetically studied. This cell line was found to have a chromosome size of 67 to 69 with many marker chromosomes involved in complex chromosomal rearrangements. Among them, the isobar chromosome on the long arm of chromosome 9 may be the characteristic aberration of lung adenocarcinoma. 9 chromosome loss in most cells, chromosome 9 short arm loss may play a role in the survival and evolution of lung adenocarcinoma.