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大鼠静脉注射盐酸川芎嗪30mg/kg后,定时取组织样品观察各脏器药物浓度的经时变化。经非房室模型分析AUC依次为肝247.9、心211.1、脾196.2、脑172.2、睾丸160.9、肺143.8、肾109.5、肌肉94.3、血78.8mg·h·L~(-1)。MRT为心脏4.27、睾丸3.41、肝2.39、肾2.28、脑2.13、肺2.12、肌肉1.77、血1.77、脾1.62h。尿中原形药排泄占用药剂量的2.8％,粪便中不能检出,药物主要经生物转化消除。以上结果表明,该
After intravenous injection of ligustrazine hydrochloride 30mg / kg, the tissue samples were taken regularly to observe the changes of drug concentration in different organs. Non-compartmental model analysis of AUC followed by liver 247.9, heart 211.1, spleen 196.2, brain 172.2, testis 160.9, lung 143.8, kidney 109.5, muscle 94.3, blood 78.8mg · h · L -1. MRT was 4.27 in the heart, 3.41 in the testis, 2.39 in the liver, 2.28 in the kidney, 2.13 in the brain, 2.12 in the lung, 1.77 in the muscle, 1.77 in the blood, 1.62 h in the spleen. Urine prototype drug excretion takes 2.8% of the dose, can not be detected in the stool, the drug is mainly eliminated by biological transformation. The above result shows that this