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来源于骨髓间叶祖细胞的人类纤维细胞可以表达许多表面分子,这些表面分子与白细胞、造血干细胞以及成纤维细胞表型有关。纤维细胞能从血液循环到达外周组织,并且根据外周组织生态位,组织纤维细胞可以分化、增殖成各种间叶细胞。这些外周组织生态位是非常重要的,它可以使纤维细胞发挥组织修复作用,这些生态位可能与慢性呼吸道疾病(如哮喘)有关,纤维细胞可以通过调节多种致呼吸道重构因子,如炎性介质、细胞因子和趋化因子等的生成和活化,最终导致呼吸道重构。
Human fibroblasts derived from bone marrow progenitor cells can express many surface molecules that are associated with phenotypes of leukocytes, hematopoietic stem cells, and fibroblasts. Fibroblasts can reach the peripheral tissue from the blood circulation, and according to the peripheral tissue niche, the tissue fibroblasts can differentiate and proliferate into various mesenchymal cells. These peripheral tissue niches are important in that they allow fibroblasts to function as tissue repair agents that may be associated with chronic respiratory diseases such as asthma. Fibroblasts can regulate the expression of several respiratory remodeling factors such as inflammatory Media, cytokines and chemokines and other generation and activation, eventually leading to respiratory remodeling.