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近年来,人们对脂质在矽肺发病中的作用引起广泛注意,石英微粒进入肺脏,引起矽肺病变,肺组织脂质代谢紊乱,磷脂含量增加,肺冲洗液磷脂含量也随着病变的发展而变化。本实验在观察石英对大鼠肺和肺冲洗液磷脂影响的同时,特别观察血磷脂含量的变化,并试用它作为判别氮氧喹哌和磷酸喹哌治疗大鼠矽肺效果的观察指标,借以探索磷脂在矽肺发病过程中的作用,为矽肺的实验研究和临床诊断提供依据。
In recent years, widespread attention has been paid to the role of lipids in the pathogenesis of silicosis. Quartz particles enter the lungs, causing silicosis, dyslipidemia in lung tissues, increased phospholipid content, and phospholipid content in lung rinse fluid as the disease progresses . In this experiment, the effects of quartz on phospholipid of lung and lung rinse were observed, and the change of phospholipid content was observed, and it was used as an indicator to evaluate the effect of nifutropecole and quipiperazine on silicosis in rats The role of phospholipids in the pathogenesis of silicosis provides the basis for the experimental study and clinical diagnosis of silicosis.