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【目的】探讨持续气道正压通气（CPAP）对合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的2型糖尿病患者胰岛素抵抗（IR）及血清脂联素水平的影响。【方法】选择本院合并OSA HS的2型糖尿病患者48例，通过3个月的CPAP治疗，观察治疗前后反映 IR的稳态模式评估（HOMA ）指数及血清脂联素水平的变化。【结果】CPAP治疗3个月后，患者的 HOMA指数较治疗前明显降低（3．58±0．76 vs 1．92±0．69），血清脂联素水平较前升高（5．42±1．35 vs 8．24±1．83），且两组相比较差异均有显著性（均 P ＜0．01）。【结论】CPAP治疗可显著改善合并OSAHS的2型糖尿病患者的IR及血清脂联素水平。“,”[Objective]To explore the effect of continuous positive airway pressure (CPAP) on insulin resist-ance(IR) and serum adiponectin level in patients with type 2 diabetes mellitus and obstructive sleep apnea hypopnea syndrome(OSAHS) .[Methods]Forty-eight patients with type 2 diabetes mellitus and OSAHS in our hospital were recruited .The homeostasis model assessment(HOMA) index and serum adiponectin level were measured before and after 3 months of CPAP treatment .[Results]Compared with before treatment ,HOMA index in patients after 3 months of CPAP treatment was significantly decreased (3 .58 ± 0 .76 vs .1 .92 ± 0 .69) ,and serum adiponectin level was significantly increased(5 .42 ± 1 .35 vs .8 .24 ± 1 .83) .There were significant difference between two groups( P <0 .01) .[Conclusion]CPAP treatment can significantly improve IR and serum adiponectin level in pa-tients with type 2 diabetes mellitus and OSAHS .