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以手术根治为主的胃癌综合治疗，五年生存率只有３７－７％，对胃癌的化疗并未取得理想的效果［１］．Ｂｃｌ２基因的异常表达，不仅与胃癌的发生有关，其抗凋亡作用的发挥，势必影响化疗效果［２］；肿瘤细胞对化疗药物存在多药耐药现象，缘于多种机制，Ｂｃｌ２基因的异?
Surgical radical treatment of gastric cancer-based comprehensive treatment, the five-year survival rate is only 37-7%, chemotherapy of gastric cancer has not achieved the desired effect [1]. Abnormal expression of Bcl2 gene is not only related to the occurrence of gastric cancer, but its anti-apoptotic effect is bound to affect the effect of chemotherapy[2]; tumor cells have multidrug resistance to chemotherapy drugs, due to a variety of mechanisms, Bcl 2 gene differences?