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目的观察参芪扶正注射液联合化疗治疗晚期乳腺癌患者的疗效、生活质量及毒副反应。方法 80例晚期乳腺癌患者随机分为两组,治疗组应用紫杉醇(TPX)+表阿霉素(EADM)化疗的同时加用参芪扶正注射液250mL,每天1次,连用7d,3周为1个周期,治疗3个周期。对照组单纯使用TPX+EADM化疗。结果治疗组有效率为57.5%,对照组为40.0%,差异有显著性(P<0.05)。治疗组生活质量Karnofsky评分高于对照组,差异有显著性(P<0.05)。治疗组血液毒副反应、胃肠道反应明显低于对照组,差异有显著性(P<0.05)。结论参芪扶正注射液配合TA方案治疗晚期乳腺癌,可提高疗效,改善患者的生活质量,降低化疗对患者的毒副反应。
Objective To observe the efficacy, quality of life and side effects of Shenqi Fuzheng injection combined with chemotherapy in patients with advanced breast cancer. Methods Eighty patients with advanced breast cancer were randomly divided into two groups. The patients in the treatment group were given Paclitaxel (TPX) + epirubicin (EADM) chemotherapy plus Shenqi Fuzheng injection 250mL once daily for 7 days for 3 weeks 1 cycle, treatment 3 cycles. The control group only used TPX + EADM chemotherapy. Results The effective rate was 57.5% in the treatment group and 40.0% in the control group, the difference was significant (P <0.05). The Karnofsky score of the treatment group was higher than that of the control group, the difference was significant (P <0.05). Blood toxicity, gastrointestinal reaction in the treatment group was significantly lower than that in the control group, the difference was significant (P <0.05). Conclusion Shenqi Fuzheng injection combined with TA regimen in the treatment of advanced breast cancer can improve the curative effect, improve the quality of life of patients and reduce the side effects of chemotherapy on patients.