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免疫组化证实６０例ＨＣＣ中有２９例ｐ１６ＩＮＫ４表达完全丧失，在２９例ｐ１６ＩＮＫ４表达完全丧失者中，有２４例ＣｐＧ硷基甲基化高达６０～８５％。相反在ｐ１６ＩＮＫ４染色较浅的肿瘤组织内甲基化水平低于２５％，在ｐ１６ＩＮＫ４染色阳性反应肿瘤组织内则未能检出
Immunohistochemistry confirmed that the expression of p16INK4 was completely lost in 29 of the 60 cases of HCC. In 29 cases of complete loss of p16INK4, 24 cases of CpG methylation up to 60-85%. In contrast, methylation levels in tumors with lighter p16INK4 staining were less than 25% and were not detected in p16INK4 staining positive tumor tissues.