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卵巢癌是妇科肿瘤中较常见的一种恶性肿瘤,也是死亡率最高的妇科肿瘤之一。目前临床主要采用手术切除及联合化疗,但总体疗效不理想。近年来,基因治疗作为肿瘤治疗的第4模式日益受到重视。现已发展了多种具有应用前景的治疗方案,如慢病毒载体方案、TRALL和Baxα结合基因方案、rAd/P53(SCH58500)基因替代方案、腺病毒介导的胸腺嘧啶激酶基因治疗方案等。这些治疗方案可分为以下四类:
Ovarian cancer is a more common malignant tumor in gynecological tumors and one of the highest mortality rates in gynecologic tumors. Currently the main use of surgical resection and combined chemotherapy, but the overall effect is not satisfactory. In recent years, gene therapy as the fourth model of cancer treatment has received increasing attention. A variety of promising therapeutic options have been developed, such as lentiviral vectors, TRALL and Baxα binding genes, rAd / P53 (SCH58500) gene replacement, and adenovirus-mediated thymidine kinase gene therapy. These treatment options can be divided into the following four categories: