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有越来越多的证据说明中枢脑啡肽在电针镇痛中起着重要作用。例如电针可使大鼠和家兔某些脑区甲硫脑啡肽(MEK)和亮脑啡肽(LEK)的含量升高,特别是下丘脑和尾核中MEK含量的升高幅度与针刺镇痛效果的优劣有明显的正相关关系;将脑啡肽抗体注入家兔中脑导水管周围灰质或脊髓蛛网膜下腔使脑啡肽中和而失活,则可显著削弱电针镇痛作用。鉴于脑啡肽的生物半寿期很短,因此设法减慢脑啡肽的降解,延长其有效作用时间,可能是加强电针镇痛的一个有效途径。
There is growing evidence that central enkephalins play an important role in EA analgesia. For example, electroacupuncture can increase the content of MEK and LEK in some brain regions of rats and rabbits, especially the increase of MEK in hypothalamus and caudate nucleus to Acupuncture analgesic effect has a significant positive correlation between pros and cons; enkephalin antibody injected into the rabbit middle cerebral aqueduct or the spinal cord subarachnoid space enkephalin neutralization inactivation, can significantly weaken the electricity Needle analgesic effect. In view of the short biological half-life of enkephalins, trying to slow the degradation of enkephalins and prolong their effective time may be an effective way to enhance the analgesia of electroacupuncture.