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采用放射免疫分析方法，测定了８只热应激兔血浆心钠素（ＡＮＰ）和血管紧张素Ⅱ（ＡｎｇⅡ）的浓度，实验环境干球温度４２℃，湿球温度３５℃。结果显示，当兔肛温（Ｔｒ）由３９９℃升至４３℃时，血浆ＡＮＰ和ＡｎｇⅡ分别由２２７７ｐｇ／ｍｌ增至２６６８ｐｇ／ｍｌ（Ｐ＜００５）和由２６０７４ｐｇ／ｍｌ增至３８３７９ｐｇ／ｍｌ（Ｐ＜００５）；与此同时，呼吸频率（ＲＲ）、心率（ＨＲ）、平均动脉压（ＭＡＰ）也增加，其中，ＭＡＰ仅增加０８ｋＰａ。当动物继续受热到１６６ｍｉｎ时，ＡＮＰ和ＡｎｇⅡ则分别增高到３３９９ｐｇ／ｍｌ和７９２３０ｐｇ／ｍｌ，但动物的ＲＲ、ＨＲ降低。ＭＡＰ由受热前的１１１ｋＰａ降至４５ｋＰａ（Ｐ＜００５），这个结果可能与热应激损伤了心血管系统，导致心肌等组织中的ＡＮＰ和ＡｎｇⅡ释放入血有关。
Radioimmunoassay was used to determine the concentration of ANP and Ang Ⅱ in eight heat-stressed rabbits. The dry-bulb temperature was 42 ℃ and the wet-bulb temperature was 35 ℃. The results showed that when the rectal temperature increased from 399 ℃ to 43 ℃, the plasma levels of ANP and AngⅡ increased from 2277pg / ml to 2668pg / ml (P <005) and from 2607 4pg / ml to 38379pg / ml (P <005). At the same time, respiratory rate (RR), heart rate (HR) and mean arterial pressure (MAP) increased as well. MAP increased only by 08kPa . When animals continued to heat up to 166 min, ANP and AngⅡ increased to 3399 pg / ml and 79230 pg / ml, respectively, but the animals had lower RR and HR. The MAP decreased from 111kPa before heating to 4.5kPa (P <005). This result may be related to the heat stress injuring the cardiovascular system, resulting in the release of ANP and AngⅡ into myocardium.