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目的 为了观察幼龄儿童(1～4岁)接种孩尔来福(Healive)甲型肝炎灭活疫苗3年后的甲肝病毒抗体滴度和下降规律。方法 对河北某山区农村曾接种500U/剂(0,3和0,6免疫程序)甲肝灭活疫苗的幼龄儿童连续3年采血,用敏感的酶联免疫吸附试验(ELISA)方法,检测其血清中的抗甲肝病毒抗体。结果 初免后1年内为抗体快速下降期,以后缓慢下降;至第3年检测时,全部接种对象仍保持甲肝抗体阳性;0,3和0,6程序组甲肝抗体滴度值>200mU/ml的分别为61.5％和73.2％。结论 Healive甲肝灭活疫苗诱导的抗体在免后3年检测仍保持较高水平。
Objective To observe the hepatitis A virus antibody titers and declination rules of Healive Hepatitis A inactivated vaccine after 3 years in young children (1 ~ 4 years old). Methods Young children who had been inoculated with 500U / dose (0, 3 and 0, 6 immune program) of hepatitis A inactivated vaccine in rural areas of Hebei Province for 3 consecutive years were collected for blood samples. Sensitive enzyme-linked immunosorbent assay (ELISA) Serum anti-hepatitis A virus antibody. Results The antibody decreased rapidly within 1 year after initial immunization, then decreased slowly. After the third year of testing, all vaccinated subjects remained positive of hepatitis A antibody. The titers of hepatitis A antibody in the 0, 3 and 0, 6 groups were> 200mU / ml 61.5% and 73.2% respectively. Conclusion The Healive hepatitis A inactivated vaccine induced high levels of antibodies in the three years after the test.