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手性(chirality)是自然界的本质属性之一。作为生命活动重要基础的大分子,如蛋白质、多糖、核酸和酶等,几乎全是手征性的,这些大分子在体内往往具有重要的生理功能。目前临床所用的药物多为低于50个原子组成的有机小分子,很大一部分也具有手性,它们的药理作用是通过与体内的大分子之间的严格手性匹配与分子识别而实现的。手性药物(chiral drug)的对映体在人体内的药理活性、代谢过程及毒性存在着显著的差异,甚至一个对映体是
Chirality is one of the essential attributes of nature. Macromolecules, such as proteins, polysaccharides, nucleic acids and enzymes, which are important foundations of life activities are almost all chiral. These macromolecules often have important physiological functions in the body. At present, most of the drugs used in clinic are mostly organic small molecules with less than 50 atoms, and a large part also have chirality. Their pharmacological effects are realized through strict chiral matching and molecular recognition with macromolecules in the body . Enantiomers of chiral drugs have significant differences in pharmacological activity, metabolic processes and toxicity in humans, and even one enantiomer is