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采用溶剂注入法制备水杨酸壳聚糖/卵磷脂纳米粒。考察了粒子结构、形貌特征及表面电位等性能,并探讨了制备工艺对药物包封率的影响。确定最佳制备工艺为:卵磷脂质量浓度20 g/L、卵磷脂与壳聚糖及水杨酸与载体的质量比分别为3∶1和1∶6、水相pH=4。所制备的水杨酸壳聚糖/卵磷脂固体纳米粒子为球形粒子、表面电位+18.7 mV、包封率及载药量可分别达到55%和8.07%。
Salicylic acid chitosan / lecithin nanoparticles were prepared by solvent injection. The particle structure, morphology and surface potential were investigated. The influence of preparation process on the entrapment efficiency was also discussed. The optimal preparation process was as follows: the mass concentration of lecithin was 20 g / L, the mass ratio of lecithin to chitosan and salicylic acid to the carrier were 3:1 and 1:6 respectively, and the pH value of the aqueous phase was 4. The prepared salicylic acid chitosan / lecithin solid nanoparticles are spherical particles, the surface potential of +18.7 mV, encapsulation efficiency and drug loading can reach 55% and 8.07% respectively.