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目的为了解生长因子对机体肿瘤细胞的作用。方法用放射免疫分析法检测了肺癌、胃癌、肝癌及肝硬化患者血清中 IGF- 和 TGF- α水平 ,并与术后进行比较。结果肺癌、胃癌和肝癌患者血清中 IGF- 和 TGF- α水平都明显高于正常人 (P<0 .0 1) ;术后两种细胞因子水平与术前各癌症组比明显下降 (P<0 .0 1)。肝硬化时与正常人比 IGF- 明显升高 (P<0 .0 1) ,TGF- α无明显改变。肝硬化组两种细胞因子均非常明显的低于肝癌组 (P<0 .0 1)。结论检测患者血清中 IGF- 和 TGF- α水平 ,有助于癌症的临床诊断和预后观察。
Objective To understand the effect of growth factors on tumor cells in the body. Methods The levels of serum IGF- and TGF-α in patients with lung cancer, gastric cancer, liver cancer and liver cirrhosis were measured by radioimmunoassay and compared with postoperative patients. Results Serum levels of IGF- and TGF-α in patients with lung cancer, gastric cancer and liver cancer were significantly higher than those in normal controls (P < 0.01). The level of two cytokines after surgery was significantly lower than that of preoperative cancer groups (P < 0 .0 1). Compared with normal controls, liver cirrhosis showed a significant increase in IGF- (P < 0.01), and there was no significant change in TGF-α. Both cytokines in the cirrhosis group were significantly lower than those in the liver cancer group (P < 0.01). Conclusion The detection of IGF- and TGF-α levels in serum of patients is helpful for the clinical diagnosis and prognosis of cancer.