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对５－单硝酸异山梨酯两种市售制剂的溶出度进行ＲＰ－ＨＰＬＣ外标法测定。流动相为甲醇－水（１∶３），检测波长２２０ｎｍ，线性范围２～８０μｇ／ｍｌ，最低检测浓度０．１μｇ／ｍｌ，ＲＳＤ小于１％。经非线性回归，证实缓释制剂的释药符合一级方程Ｄｔ＝Ｄｍａｘ［７０％（１－ｅ－ｋ（ｔ－ｔ０）＋３０％］。
The dissolution of two commercial isosorbide 5-mononitrate samples was determined by RP-HPLC external standard method. The mobile phase was methanol-water (1: 3). The detection wavelength was 220 nm. The linear range was 2-80 μg / ml. The lowest detection concentration was 0.1 μg / ml with RSD less than 1%. The results of non-linear regression showed that the release of sustained-release preparations accord with the first order equation Dt = Dmax [70% (1-e-k (t-t0) +30%].