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目的:探讨成人肾母细胞瘤的诊断和治疗方法。方法:回顾性分析天津医科大学第二医院7例成人肾母细胞瘤的临床资料。其中男4例,女3例,平均年龄33岁,肿瘤平均直径9cm。结果:7例患者按照美国国家肾母细胞瘤研究组分期:Ⅰ期2例,Ⅱ期3例,Ⅲ期1例,Ⅳ期1例。7例均行根治性肾切除术,术后病理均证实为肾母细胞瘤,辅以放疗及化疗。随访时间3~72个月,中位随访时间30个月,其中1例患者失访,3例患者已经死亡,1例患者出现肿瘤复发并带瘤生存,2例患者无瘤生存,中位生存时间36个月。结论:成人肾母细胞瘤是一种比较少见的恶性肿瘤,术前确诊困难,病理检查是诊断成人肾母细胞瘤的金标准。早期诊断、手术治疗、辅以放疗和化疗等可明显提高治愈率并改善预后。
Objective: To investigate the diagnosis and treatment of adult Wilms tumor. Methods: The clinical data of 7 adult nephroblastomas in the Second Hospital of Tianjin Medical University were retrospectively analyzed. Including 4 males and 3 females, mean age 33 years, the average tumor diameter 9cm. Results: According to the American National Nephroblastoma study group, 7 patients were divided into two groups: stage Ⅰ, stage Ⅲ, stage Ⅲ, stage Ⅲ, stage Ⅳ, stage Ⅳ. Seven patients underwent radical nephrectomy. All postoperative pathology confirmed as nephroblastoma combined with radiotherapy and chemotherapy. The follow-up time ranged from 3 months to 72 months. The median follow-up time was 30 months. One patient was lost to follow-up, three patients died, one patient had tumor recurrence and tumor-bearing survival, and two patients had tumor-free survival and median survival Time 36 months. Conclusion: Adult Wilms ’tumor is a rare malignant tumor with difficult diagnosis before operation. Pathological examination is the gold standard for the diagnosis of adult Wilms’ tumor. Early diagnosis, surgery, adjuvant radiotherapy and chemotherapy can significantly improve the cure rate and improve the prognosis.