论文部分内容阅读
目的分析和探讨枣庄地区新生儿败血症的临床特点、病原学分布及药敏情况,指导合理用药。方法以枣庄市妇幼保健院及滕州市妇幼保健院的173例新生儿败血症患儿为研究对象,对其进行细菌鉴定及药敏试验。结果 173例血培养阳性标本中,革兰阳性菌114株(65.90%);其中以凝固酶阴性葡萄球菌和金黄色葡萄球菌居多,与其他细菌有显著性差异(P<0.05),两者对青霉素和红霉素普遍耐药;革兰阴性菌感染的主要致病菌有肺炎克雷伯杆菌和大肠埃希菌,对头孢唑啉、氨苄西林和头孢他啶均具有较高的敏感性。结论凝固酶阴性葡萄球菌、金黄色葡萄球菌、肺炎克雷伯杆菌和大肠埃希菌是枣庄地区新生儿败血症的主要病原菌,它们对大多数抗生素具有高度敏感性。
Objective To analyze and discuss the clinical features, pathogenic distribution and drug susceptibility of neonatal sepsis in Zaozhuang region and to guide the rational use of drugs. Methods 173 cases of neonatal sepsis in Zaozhuang Maternal and Child Health Hospital and Tengzhou Maternal and Child Health Hospital were studied for bacteria identification and drug sensitivity test. Results Of the 173 blood culture positive samples, there were 114 Gram-positive bacteria (65.90%), of which coagulase-negative Staphylococcus aureus and Staphylococcus aureus were the most common, with significant difference (P <0.05) Penicillin and erythromycin are generally drug-resistant; Gram-negative bacteria are the main pathogens Klebsiella pneumoniae and Escherichia coli, cefazolin, ampicillin and ceftazidime are highly sensitive. Conclusion Coagulase-negative Staphylococcus aureus, Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli are the main pathogens of neonatal sepsis in Zaozhuang area. They are highly sensitive to most antibiotics.