一种非离子型造影剂的经胎盘排出途径

• 作 者: Vanhaesebrouck P. Verstraete A.G. De Praeter C. 韩浩
• 机 构: Department of Neonatology Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium,
• 出 处: 世界核心医学期刊文摘(儿科学分册)
• 发表日期: 2005年12期
• 关键词: 非离子型造影剂 胎盘 毒性损害 造影剂 孕妇 临界性 新生儿 排泄物 胎儿 尿液

We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hyperthyrotropinaemia were observed in the infant. Moreover, crossing of the fetal bloodbrain barrier was demonstrated by detection of the angiographic material in CSF and thus direct fetal neurotoxic effects cannot be excluded. Conclusion:These widely used contrast media may cross the placenta and accumulate in various fetal tissues in significant amounts causing possible neonatal toxicity. Therefore the perinatal safety of these diagnostic agents should at least be questioned.

We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hyperthyrotropinaemia were observed in the infant. Moreover, crossing of the fetal bloodbrain barrier was demonstrated by detection of the angiographic material in CSF and thus direct fetal neurotoxic effects can not be excluded. Conclusion: These widely used contrast media may cross be placenta and accumulate in various fetal tissues in likely various fetal tissues. of these diagnostic agents should at least be questioned.