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[目的]研究鼻咽癌中Ki67和CD44v6的表达及其关系。[方法]采用免疫组化S-P法检测23例鼻咽慢性炎、62例鼻咽癌(38例伴有淋巴结转移)组织中Ki67和CD44v6的表达情况。[结果]鼻咽慢性炎和鼻咽癌中Ki67阳性表达率分别为71.0%、13.0%,差异有统计学意义(P<0.05)。CD44v6在鼻咽癌和鼻咽慢性炎中的阳性率分别为77.4%、17.4%,差异有统计学意义(P<0.05)。鼻咽癌转移组Ki67和CD44v6的阳性率分别为84.2%、89.5%,明显高于非转移组的50.0%、58.3%(P<0.05)。鼻咽癌中Ki67和CD44v6表达呈正相关(r=0.452,P<0.05)。[结论]Ki67和CD44v6在鼻咽癌中的高表达协同参与了鼻咽癌的增殖和转移。
[Objective] To study the expression of Ki67 and CD44v6 in nasopharyngeal carcinoma and their relationship. [Method] The immunohistochemical S-P method was used to detect the expression of Ki67 and CD44v6 in 23 cases of chronic nasopharyngitis and 62 cases of nasopharyngeal carcinoma (38 cases with lymph node metastasis). [Results] The positive rates of Ki67 in nasopharyngeal chronic and nasopharyngeal carcinoma were 71.0% and 13.0%, respectively, with significant difference (P <0.05). The positive rates of CD44v6 in nasopharyngeal carcinoma and nasopharyngeal chronic inflammation were 77.4% and 17.4%, respectively, with significant difference (P <0.05). The positive rates of Ki67 and CD44v6 in nasopharyngeal carcinoma group were 84.2% and 89.5%, respectively, which were significantly higher than those in non-metastasis group (50.0% and 58.3%, P <0.05). There was a positive correlation between Ki67 and CD44v6 expression in NPC (r = 0.452, P <0.05). [Conclusion] The high expression of Ki67 and CD44v6 in nasopharyngeal carcinoma is synergistically involved in the proliferation and metastasis of nasopharyngeal carcinoma.