论文部分内容阅读
目的探讨HLA-DQ基因与中国北方汉族衣原体引起盆腔炎的相关性。方法采用聚合酶链反应/序列特异寡核苷酸探针(PCR-SSO)方法检测35例北方汉族衣原体引起盆腔炎患者的HLA-DQ等位基因。结果与98例健康对照比较,盆腔炎患者HLA-DQA1*0501、HLA-DQB1*0301等位基因的频率明显增高,且与CHSP60抗体反应相关。结论该结果可能为进一步揭示衣原体引起盆腔炎的易感基因和免疫遗传发病机制提供线索。
Objective To investigate the relationship between HLA-DQ gene and chlamydia causing Han Chinese cholera in northern China. Methods Polymerase chain reaction / sequence specific oligonucleotide probes (PCR-SSO) were used to detect HLA-DQ alleles in 35 North Han Chinese patients with pelvic inflammatory disease. Results Compared with 98 healthy controls, the frequencies of HLA-DQA1 * 0501 and HLA-DQB1 * 0301 alleles were significantly higher in patients with pelvic inflammatory disease and correlated with CHSP60 antibody responses. Conclusion The results may provide clues for further revealing the chlamydial susceptibility genes and immunological genetic pathogenesis of pelvic inflammatory disease.