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目的探讨早期应用多巴胺联合纳洛酮对中重度缺氧缺血性脑病新生儿神经行为发育的影响。方法选取2010年4月-2012年4月济源市妇幼保健院收治的90例中重度缺氧缺血性脑病新生儿为研究对象,将其随机分为对照组和治疗组,对照组45例给予常规临床治疗,治疗组45例在常规治疗的基础上辅以多巴胺联合纳洛酮治疗,对比两组患儿的临床疗效。结果治疗组患儿的DQ值和Gesell各能区评分明显高于对照组患儿,两组对比差异明显,具有统计学意义(P<0.05)。结论早期应用多巴胺联合纳洛酮治疗对中重度缺氧缺血性脑病新生儿临床效果显著,可有效改善患儿神经行为的发育情况,值得临床推广和应用。
Objective To investigate the effect of early application of dopamine combined with naloxone on neurobehavioral development in neonates with moderate and severe hypoxic-ischemic encephalopathy. Methods From April 2010 to April 2012, 90 newborn infants with moderate-severe hypoxic-ischemic encephalopathy admitted to Jiyuan MCH hospital were selected as study subjects and randomly divided into control group and treatment group, and 45 cases in control group Routine clinical treatment, 45 cases of treatment group on the basis of conventional treatment combined with dopamine and naloxone treatment, the clinical efficacy of two groups were compared. Results The scores of DQ and Gesell in each treatment group were significantly higher than those in the control group. The differences between the two groups were statistically significant (P <0.05). Conclusion Early application of dopamine combined with naloxone in neonates with moderate-severe hypoxic-ischemic encephalopathy clinical effect is significant, can effectively improve the development of children’s neurological behavior, worthy of clinical promotion and application.