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目的探讨醋酸生长抑素治疗肺结核大咯血的疗效及安全性。方法 65例肺结核大咯血患者,随机分为观察组(33例)和对照组(32例)。观察组患者在一般治疗基础上给予醋酸生长抑素治疗,对照组患者在一般治疗基础上加用垂体后叶素治疗。比较两组治疗效果。结果观察组总有效率为87.9%,高于对照组的65.6%,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论醋酸生长抑素治疗肺结核大咯血高效、安全、不良反应少,使用方便,尤其对内科各种常规止血药物治疗无效,或患者不能耐受垂体后叶素时应用价值更大,值得临床推广应用。
Objective To investigate the efficacy and safety of somatostatin acetate in the treatment of tuberculosis with hemoptysis. Methods Sixty-five patients with tuberculosis and hemoptysis were randomly divided into observation group (33 cases) and control group (32 cases). Patients in observation group were treated with somatostatin acetate on the basis of general treatment, while patients in control group were treated with pituitrin on the basis of general treatment. Compare the treatment effect of two groups. Results The total effective rate in the observation group was 87.9%, which was higher than that in the control group (65.6%), the difference was statistically significant (P <0.05); the adverse reaction rate in the observation group was lower than that in the control group (P <0.05) . Conclusion Somatostatin is effective and safe in treating pulmonary tuberculosis with hemoptysis. It is easy to use, especially for the ineffective treatment of various conventional hemostatic drugs in patients with medical conditions. It is worth to be more widely used in clinical application.