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目的:探究外伤急诊大出血病人在大量输血后凝血指标变化状况。方法:研究对象为2014年8月-2016年8月收入的98例外伤急诊大出血病人,输血量≥1500ml的49例创伤输血病人为观察组,选取同期输血量<1500ml的49例创伤输血病人为对照组。结果:两组病人输血前组间数据无明显差异(P>0.05),输血后8h、24h观察组凝血酶时间、活化部分凝血酶原时间、凝血酶原时间显著比对照组高(P<0.05),输血后72h组间数据无明显差异(P>0.05)。结论:对大出血病人进行大量输血补充血容量的临床治疗具有重要意义,但大量输入库存血可对血小板及凝血四项指标造成负面影响,应在输血过程中密切观察各项指标做好准备工作。
Objective: To investigate the changes of coagulation index after massive blood transfusion in patients with traumatic emergency hemorrhage. Methods: Forty-nine traumatic patients with transfusion of blood transfusion more than 1500ml were enrolled in the study. Among them, 49 cases of traumatic transfusion patients whose transfusion volume was less than 1500ml were selected as the observation group from August 2014 to August 2016, Control group. Results: There was no significant difference between the two groups before transfusion (P> 0.05). The time of prothrombin time, prothrombin time and prothrombin time in the observation group at 8h and 24h after transfusion were significantly higher than those in the control group (P <0.05) ), There was no significant difference between 72h after transfusion (P> 0.05). Conclusion: It is of great significance to carry out a large number of blood transfusions in patients with massive hemorrhage. However, a large amount of blood transfusion may have a negative impact on the four indexes of platelets and blood clotting. The indicators should be closely observed during transfusion.