Potential role of DNA-dependent protein kinase in cellular resistance to ionizing radiation

• 作 者: LINing ZHANG Hong WANG Yanling
• 机 构: InstituteofModernPhysics,KeyLaboratoryofHeavylonRadiationMedicineofGansuProvince,GraduateSchoolofChi
• 出 处: 核技术：英文版
• 发表日期: 2009年2期
• 关键词: DNA依赖蛋白激酶 细胞增殖率 电离辐射 潜在作用 X射线照射 放射敏感性 哺乳动物细胞 争端解决机制 DNA-dependent protein kinase
• 基金项目: Supported by National Natural Science Foundation of China （10675151） and Western Talent Program of Chinese Acadezny of Sciences （0860260XBO）.

In this paper,we study the ability of DNA-PK-deficient(M059J) and -proficient(M059K) cells to undergo the rate of cellular proliferation,cell cycle distribution and apoptosis after 10 Gy X-ray irradiation,and the role of DNA-PK in radiosensitivity.The res