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目的:研究血栓弹力图在经皮冠状动脉介入治疗(PCI)患者中,使用血栓弹力图所测定的血小板抑制率的波动及临床疗效作用。方法:选取我院2012年1月份至2013年12月份收治的200例冠心病PCI治疗患者,应用血栓弹力图分析仪测定其二磷酸腺苷(ADP)途径诱导的血小板抑制率数据,根据抑制率差异分为3组,抑制率>70%的为合格组,抑制率<30%的为不合格组,入选不合格组再次分为2组,1组保持常规剂量治疗不变,另一组为大剂量治疗组。结果:随访半年的记录,记录一般情况及严重心脏不良事件发生情况。结果:随访的6个月中,共发生不良事件28例,其中合格组10例(9.6%),常规治疗组11例(22.4%),大剂量治疗组7例(14.9%),3组中不良事件发生率比常规治疗组大于大剂量治疗组,大剂量治疗组大于合格组,统计学上有明显差异(P<0.05)。结论:血栓弹力图在PCI患者抗血小板治疗中应用具有一定的指导意义。
PURPOSE: To investigate the fluctuation of platelet inhibition rate and the clinical effect of thromboelastography in patients undergoing percutaneous coronary intervention (PCI) using thromboelastometry. Methods: 200 patients with PCI treated in our hospital from January 2012 to December 2013 were enrolled in this study. Data of platelet inhibition induced by adenosine diphosphate (ADP) pathway were measured by thrombelastography analyzer. According to the inhibition rate The differences were divided into three groups, the inhibition rate of> 70% for the qualified group, the inhibition rate of <30% for the unqualified group, selected unqualified group was divided into two groups, one group to maintain the conventional dose of treatment unchanged, the other group High-dose treatment group. Results: Follow-up six months of records, record the general situation and serious adverse cardiac events. Results: During the 6 months follow-up, 28 patients had adverse events, of which 10 were eligible patients (9.6%), 11 patients (22.4%) were treated with conventional therapy and 7 patients (14.9%) were treated with high dose therapy The incidence of adverse events was higher than that of the conventional treatment group and the large dose treatment group was larger than the qualified group, with statistically significant difference (P <0.05). Conclusion: The thrombus elastography has some guiding significance in antiplatelet therapy of PCI patients.