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目的探讨血清糖类抗原125(CA125)、蛋白激酶B(AKT)、磷酸化蛋白激酶B(p-AKT)水平联合诊断子宫内膜肿瘤的临床价值。方法选取子宫内膜恶性肿瘤的患者100例作为A组,子宫内膜良性肿瘤的患者100例作为B组,另选取体检正常的健康者100例作为C组,分别检测3组血清CA125、AKT和p-AKT的水平并进行比较。结果 B组血清CA125、AKT、p-AKT水平阳性率均显著高于C组;A组血清CA125、AKT、p-AKT水平阳性率均显著高于B组。结论血清CA125、AKT、p-AKT阳性对子宫内膜肿瘤的诊断具有重要的临床价值。
Objective To investigate the clinical value of serum carbohydrate antigen 125 (CA125), protein kinase B (AKT) and phosphorylated protein kinase B (p-AKT) in the diagnosis of endometrial tumors. Methods One hundred patients with endometrial cancer were selected as group A, 100 as benign endometrial tumors as group B, and 100 healthy subjects with normal endometrium as group C. Serum levels of CA125, AKT and p-AKT levels and compared. Results The positive rates of serum CA125, AKT and p-AKT in group B were significantly higher than those in group C. The positive rates of serum CA125, AKT and p-AKT in group A were significantly higher than those in group B. Conclusion Serum CA125, AKT, p-AKT positive diagnosis of endometrial cancer has important clinical value.