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目的 :探讨 PTEN/ MMAC1/ TEP1与大肠癌的发生 ,发展的相关性。方法 :应用 S- P免疫组织化学方法检测 2 3例正常大肠粘膜、 2 8例大肠腺瘤和 75例大肠癌组织中 PTEN/ MMAC1/ TEP1蛋白的表达情况。结果 :2 3例正常大肠粘膜组织中PTEN蛋白表达阳性率为 91.3% (2 1/ 2 3) ,2 8例大肠腺瘤组织中 PTEN蛋白表达阳性率均为 89.3% (2 5 / 2 8) ,75例大肠癌组织中 PTEN蛋白表达阳性率为 6 8% (5 1/ 75 ) ,与正常大肠粘膜及大肠腺瘤差异有显著意义 (P <0 .0 1) ;有淋巴结转移的2 8例大肠癌阳性率为 43% (12 / 2 8) ,无淋巴结转移的 47例大肠癌阳性率为 83% (39/ 47) ,两者差异有显著意义 (P <0 .0 1) ;有远处器官转移的 2 3例大肠癌中阳性率为 43.5 % (10 / 2 3) ,无远处器官转移的 5 2例大肠癌阳性率为 78.8% (4 1/ 5 2 ) ,差异有显著意义 (P〈0 .0 1) ;6 0例大肠腺癌中蛋白表达阳性率为 81.2 % (4 9/ 6 0 ) ,15例粘液癌蛋白表达阳性率为 13.3% (2 / 15 ) ;两者之间有显著性差异 (P <0 .0 1) ;6 0例大肠腺癌中高 /中分化大肠腺癌 37例表达阳性率为 97.3% (36 / 37) ,低分化大肠腺癌 2 3例中表达阳性率为 5 6 .5 % (13/ 2 3) ,两者差异有显著意义 (P <0 .0 1)。结论 :PTEN/ MMAC1/ TEP1与大肠癌的发生、发展有相关
Objective: To investigate the correlation between PTEN/MMAC1/TEP1 and the development and progression of colorectal cancer. Methods : The expression of PTEN/MMAC1/TEP1 protein in 23 cases of normal mucosa, 28 cases of colorectal adenoma and 75 cases of colorectal cancer was detected by S-P immunohistochemistry. RESULTS: The positive rate of PTEN protein expression in 23 cases of normal colorectal mucosa was 91.3% (21/23). The positive rate of PTEN protein expression in 28 cases of colorectal adenoma was 89.3% (2 5/8). The positive rate of PTEN protein expression in 75 cases of colorectal cancer was 6 8% (5 1/75), which was significantly different from that of normal colorectal mucosa and colorectal adenoma (P < 0.01). There was 2 8 of lymph node metastasis. The positive rate of colorectal cancer was 43% (12/28). The positive rate of colorectal cancer without lymph node metastasis was 83% (39/47). There was a significant difference between them (P < 0.01); The positive rate of distant metastasis in 23 cases of colorectal cancer was 43.5 % (10 / 23), and the positive rate of 52 colorectal cancer without distant organ metastasis was 78.8% (4 1 / 5 2). The difference was significant. Significance (P<0.01); The positive rate of protein expression in 60 cases of colorectal adenocarcinoma was 81.2% (4 9/60), and the positive rate of myxoma protein expression was 15.3% (2/15); There was a significant difference between the two groups (P < 0.01); the positive rate of high/moderately differentiated colorectal adenocarcinoma among the 60 colorectal adenocarcinomas was 97.3% (36/37), poorly-differentiated colorectal adenocarcinoma 2 3 The positive rate in the cases was 5 6 .5% (13/23). The difference was Significant (P < 0.01). Conclusion :PTEN/ MMAC1/ TEP1 is associated with the occurrence and development of colorectal cancer