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研究表明，金丝桃甙（ＨｙＰ）对兔乳头肌模型，与维拉帕米（Ｖｅｒ）一样，呈剂量依赖性抑制ＣａＣｌ２诱发的正性肌力作用，使ＣａＣｌ２的量－效曲线显著右下移动，但不平行，可能系非竞争性拮抗；对豚鼠心室肌动作电位模型，Ｈｙｐ可显著缩短动作电位二相平台期，而对膜静息电位、动作电位零相上升幅度和速率及动作电位时程无明显影响；在小鼠心房组织标本上，Ｈｙｐ和Ｖｅｒ一样，可抑制高钾诱发的４５Ｃａ内流。上述结果提示Ｈｙｐ对钙内流有一定阻滞作用。
Studies have shown that hyperparaplex (HyP) in rabbit papillary muscle model, as with verapamil (Ver), a dose-dependent inhibition of CaCl2-induced positive inotropic effect, CaCl2 dose-response curve significantly lower right Hyp can significantly shorten the biphasic plateau phase of action potential, but the amplitude and rate of zero phase increase and velocity of action potential and action potential Hypoxemia and time course had no significant effect. In mouse atrial tissue samples, Hyp and Ver were able to inhibit the influx of 45Ca induced by high potassium. The above results suggest that Hyp has a certain retardation effect on calcium influx.