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目的探讨交变磁场介导的二巯基丁二酸(DMSA)-Fe3O4纳米磁流体热疗治疗兔VX2肿瘤的疗效。方法建立20只兔后肢VX2软组织肿瘤模型,随机分为4组:A组(对照组)、B组(磁流体局部注射组+热疗)、C组(磁流体动脉灌注组+热疗)、D组(磁流体静脉注射组+热疗),每组5只。成瘤2周后CT测量肿瘤大小。结果 B组和C组的肿瘤中心区[(46.01±1.97)℃和(40.38±1.50)℃]和肿瘤边缘区[(40.35±1.36)℃和(42.57±1.80)℃]的温度显著高于正常肌肉组织[(35.73±1.32)℃和(35.37±1.55)℃]和直肠[(35.69±1.05)℃和(35.25±1.15)℃](P<0.05);A组及D组肿瘤区域温度无明显增高。治疗后14d,B组和C组肿瘤生长率分别为(441.04±29.61)%和(354.81±59.51)%,明显低于A组的(1119.90±179.40)%和D组的(1099.90±215.11)%(P<0.05)。结论交变磁场介导的DSMA-Fe3O4纳米磁流体热疗能明显抑制兔VX2肿瘤生长。
Objective To investigate the effect of alternating magnetic field mediated dimercaptosuccinic acid (DMSA) -Fe3O4 nanofluid thermotherapy on VX2 tumors in rabbits. Methods 20 hindlimb VX2 soft tissue tumor models were established and randomly divided into 4 groups: group A (control group), group B (magnetic fluid local injection group + hyperthermia group), group C (magnetic fluid arterial perfusion group + hyperthermia group) Group D (magnetic fluid intravenous injection group + hyperthermia), 5 rats in each group. Two weeks after tumor formation, tumor size was measured by CT. Results The temperature in the tumor center [(46.01 ± 1.97) ° C and (40.38 ± 1.50 ° C)] and tumor marginal zone [(40.35 ± 1.36) ° C and (42.57 ± 1.80 ° C)] in group B and group C were significantly higher than those in normal (35.73 ± 1.32) ℃ and (35.37 ± 1.55) ℃, rectum (35.69 ± 1.05) ℃ and (35.25 ± 1.15) ℃, respectively (P <0.05). There was no significant difference in the temperature of tumor in group A and group D Increase. At 14 days after treatment, the tumor growth rates of group B and group C were (441.04 ± 29.61)% and (354.81 ± 59.51)%, respectively, which were significantly lower than those of group A (1119.90 ± 179.40)% and group D (1099.90 ± 215.11)% (P <0.05). Conclusion Alternating magnetic field mediated DSMA-Fe3O4 nanofluid thermotherapy can significantly inhibit the growth of rabbit VX2 tumors.