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同特异性免疫测定ELISA法检测了32例酒精性肝硬化患者和10名健康人血清中肿瘤坏死因子受体的水平。酒精性肝硬化患者两种可溶性肿瘤坏死因子受体(P55、P75)均明显高于健康组(P<0.01),肝硬化代偿期与失代偿期患者比较有显著差异(P值分别<0.005,<0.01)。这些结果提示循环中可溶性肿瘤坏死因子受体(STNFR)的水平与肝硬化和疾病的进展程度呈正相关。
The serum levels of tumor necrosis factor receptor (TNF) in 32 patients with alcoholic cirrhosis and 10 healthy people were detected by ELISA with specific immunoassay. The levels of two soluble tumor necrosis factor receptors (P55 and P75) in patients with alcoholic cirrhosis were significantly higher than those in healthy controls (P <0.01). There was significant difference between patients with decompensated and decompensated cirrhosis (P < 0.005, <0.01). These results suggest that the circulating level of soluble tumor necrosis factor receptor (STNFR) is positively correlated with the degree of progression of cirrhosis and disease.