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目的探讨腹腔镜术后联合应用米非司酮或孕三烯酮治疗子宫内膜异位症的疗效。方法行腹腔镜手术的子宫内膜异位症患者91例随机分为三组:A组31例,采用米非司酮治疗;B组32例,采用孕三烯酮烯酮治疗;C组28例,不用药。随访12-24个月,比较术后疗效、复发率、妊娠率和药物相关不良反应等。结果 A组和B组有效率分别为51.61%和71.88%,明显高于C组的35.71%(P<0.05);A组和B组复发率低于C组(6.25%和9.68%vs.53.57%)(P<0.01)。三组术后妊娠率相仿(P>0.05)。结论子宫内膜异位症腹腔镜术后联合应用孕三烯酮或米非司酮可显著提高疗效,降低术后复发率;但未能显著提高妊娠率。
Objective To investigate the efficacy of laparoscopic combined with mifepristone or gestrinone in the treatment of endometriosis. Methods 91 cases of endometriosis undergoing laparoscopic surgery were randomly divided into three groups: 31 cases in group A treated with mifepristone; 32 cases in group B treated with gestodene ketones; group C 28 For example, do not medication. The patients were followed up for 12-24 months. The postoperative efficacy, relapse rate, pregnancy rate and drug-related adverse reactions were compared. Results The effective rates in group A and group B were 51.61% and 71.88%, respectively, which were significantly higher than those in group C 35.71% (P <0.05). The recurrence rates in group A and group B were lower than those in group C (6.25% vs 9.68% vs.53.57 %) (P <0.01). Three groups of postoperative pregnancy rates were similar (P> 0.05). Conclusion The combination of gestrinone or mifepristone after laparoscopic endometriosis can significantly improve the curative effect and reduce the postoperative recurrence rate; however, it can not significantly improve the pregnancy rate.