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目的:了解我院抗感染药致不良反应(ADR)的发生情况,探讨引起ADR发生的因素。方法:对2008～2009年我院上报的442例抗感染药致ADR病例报告按性别、年龄、药物类别、给药途径、ADR的临床表现等进行统计分析。结果:涉及ADR的药品65种,头孢菌素类居首位,其次为喹诺酮类;用药途径以静脉给药为主;主要ADR类型为皮肤及其附件损害;严重ADR 44例。结论:继续加强抗感染药ADR监测,尤其应加强不易观察的及慢性ADR的监测。
Objective: To understand the incidence of anti-infective drug-induced adverse reactions (ADR) in our hospital and to explore the factors that cause ADR. Methods: A total of 442 ADR cases reported in our hospital from 2008 to 2009 were analyzed statistically according to sex, age, drug category, route of administration and clinical manifestations of ADR. Results: There were 65 kinds of drugs involving ADR, with cephalosporins ranking the top, followed by quinolones. The main route of administration was intravenous administration. The main types of ADR were lesions of the skin and its appendages and 44 cases of severe ADR. CONCLUSIONS: ADR monitoring of anti-infectives should continue to be strengthened. In particular, monitoring of unobservable and chronic ADR should be strengthened.