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目的：通过临床药师参与1例晚期结肠癌患者的化疗方案制定，探讨临床药师在合理用药中发挥的作用。方法：临床药师积极参与了该患者治疗方案制定的全过程，针对治疗组有关 KRAS 13突变是否可以使用西妥昔单抗的争议进行了循证调研，Meta 分析，给出合理的治疗建议，并对患者及护士进行用药教育，保证药物治疗质量。结果：临床药师参与治疗实践，提高了临床治疗效果。患者用药后肿瘤获得明显缓解，并无重大不良反应发生。结论：临床药师参与临床药物治疗实践，有利于提高临床药物治疗水平，为病人提供个体化药学服务。“,”OBJECTIVE To investigate the role of a pharmacist in rational drug use by participating in 1 case of metastasis colon cancer with KRAS 13 mutation. METHODS The clinical pharmacist actively participated in the patient’s treatment practice. According to the debate on whether patients with KRAS 13 mutation could be treated with cetuximab, clinical pharmacist conducted the evidenced-based research and meta analysis, and gave the rational treatment suggestion. In addtion, education was made to guarantee the medical quality. RESULTS The clinical pharmacist helped improve the clinical treatment effect. The patient get significant relief of tumor after treatment, and no severe adverse events occured. CONCLUSION Involvement of clinical pharmacist in therapeutic practice could improve the safety and efficacy of pharmacotherapy, and provide individualized pharmaceutical care for the patients.