论文部分内容阅读
为探索小剂量米非司酮用于紧急避孕的效果,观察291例健康、月经规律妇女,在避孕失败或无保护的性生活后72小时内服药,并随机分为3组,组1(n=99)单次口服25mg米非司酮;组Ⅱ(n=92)单次服用10mg米非司酮;组Ⅲ(n=100)单次服用5mg米非司酮。3组共4例失败。避孕有效率分别为83.8％、84.92％和70.5％,三组间无明显差异。服低剂量米非司酮后副反应发生率低,对月经影响小。观察5例服用5mg米非司酮妇女子宫内膜形态,3例出现子宫内膜发育不同步,2例变化不明显。结果表明,5mg米非司酮用于紧急避孕,临床上虽有一定成功率,但对子宫内膜影响不肯定,尚需进一步研究,故应谨慎用于临床。
In order to explore the effect of low-dose mifepristone on emergency contraception, 291 healthy, menstrual women were observed within 72 hours after contraceptive failure or unprotected sex and were randomly divided into three groups: group 1 (n = 99) received a single oral dose of 25 mg of mifepristone; group II (n = 92) received 10 mg of mifepristone alone; and group III (n = 100) received 5 mg of mifepristone alone. A total of 4 cases failed in 3 groups. The effective rates of contraception were 83.8%, 84.92% and 70.5% respectively, with no significant difference among the three groups. The low incidence of side effects after taking mifepristone, little effect on the menstrual. The endometrial morphology of 5 women who took 5 mg mifepristone was observed. There was no synchronous development of endometrium in 3 cases, and no obvious change in 2 cases. The results showed that 5mg mifepristone for emergency contraception, although a certain clinical success rate, but the impact on the endometrium not sure, still needs further study, it should be used with caution in clinical.