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碱性成纤维细胞生长因子(BFGF)及转化生长因子β1(TGF-β1)是肝纤维化促进因子,是激活肝星状细胞(HSC)并促进其表达细胞外基质(ECM)关键因子,在肝纤维化的发展中具有重要作用。现就其二者与肝纤维化关系的研究进展做一综述。1碱性成纤维细胞生长因子的特征、合成及表达1·1 BFG
Basic fibroblast growth factor (BFGF) and transforming growth factor-β1 (TGF-β1) are the factors that promote hepatic fibrosis and activate hepatic stellate cells (HSCs) and promote the expression of extracellular matrix (ECM) Liver fibrosis plays an important role in the development. Now on both the relationship between liver fibrosis and its research progress is reviewed. 1 Basic fibroblast growth factor characteristics, synthesis and expression of 1.1 BFG