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作者测定了27例终末期肾功能衰竭(ESRF)患者口服葡萄糖耐量试验(OGTT)时的血清胰多肽(SPP)水平。结果显示ESRF患者的SPP明显高于正常对照组;透析治疗不能纠正ESRF患者的高胰多肽血症;同种异体肾移植后SPP可完全恢复正常;SPP水平与血糖和血清胰岛素水平无明显相关。肾脏是胰多肽代谢的重要场所,ESRF患者SPP浓度升高与其肾功能衰竭有关,而高胰多肽血症可能是ESRF患者消化道症状的原因之一。
The authors measured serum pancreatic polypeptide (SPP) levels in oral glucose tolerance test (OGTT) in 27 patients with end-stage renal failure (ESRF). The results showed that the SPP in patients with ESRF was significantly higher than that of the normal control group; dialysis treatment could not correct the hyperpatyspeptidemia in ESRF patients; SPP completely returned to normal after allogeneic kidney transplantation; SPP level had no significant correlation with blood glucose and serum insulin level. Kidney is an important site of pancreatic polypeptide metabolism, ESRF patients with elevated serum SPP concentration related to its renal failure, and hyperpilysiamia may be one of the causes of gastrointestinal symptoms in ESRF patients.