头孢米诺在甲硝唑、替硝唑注射液中的稳定性考察

• 作 者: 李莉
• 机 构: 武汉大学人民医院药学部 武汉 430060
• 出 处: 中国药师
• 发表日期: 2007年08期
• 关键词: 头孢米诺 甲硝唑 替硝唑注射液 配伍稳定性

目的:考察头孢米诺与甲硝唑、替硝唑注射液配伍的稳定性。方法:用双波长分光光度法测定头孢米诺、紫外分光光度法测甲硝唑、替硝唑的含量,考察配伍液不同时间的pH、物理变化、含量。结果:25℃条件下,头孢米诺在甲硝唑、替硝唑注射液中8 h的含量分别为93.52%,91.52%,而甲硝唑、替硝唑含量在72 h分别为97.95%,93.79%;甲硝唑组72 h无pH、颜色及其他物理变化;替硝唑组72 h颜色为淡黄,其他无改变。结论:头孢米诺可与甲硝唑、替硝唑注射液配伍。

Objective: To investigate the stability of compatibility between cefminox and metronidazole and tinidazole injection. Methods: The concentration of metronidazole and tinidazole was determined by dual-wavelength spectrophotometry with cefminox and ultraviolet spectrophotometry. The pH, physical changes and contents of compatibility solution were investigated. Results: At 25 ℃, the content of cefmenoxime in metronidazole and tinidazole injection for 8 h was 93.52% and 91.52% respectively, while the content of metronidazole and tinidazole was 97.95% in 72 h, 93.79%. There was no pH, color and other physical changes in the metronidazole group for 72 h. The color of the tinidazole group was yellow for 72 h, while the others did not change. Conclusion: Cefminox is compatible with metronidazole and tinidazole injection.