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目的探讨类风湿因子(RF)和抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断价值。方法随机抽取73例RA患者、72例非RA患者和65例健康人群的血清,用免疫透射比浊法测定RF,ELISA测定抗-CCP抗体,分别计算RF和抗-CCP抗体检测结果的敏感度、特异性和一致性等。结果 RA组患者抗-CCP抗体及RF的检测结果均显著高于非RA组和健康对照组(P<0.01)。RF和抗-CCP抗体诊断RA的敏感度分别为75.3%和69.9%、特异度分别为75.2%和97.8%;抗-CCP抗体和RF的RA阳性检测率相仿(P>0.05)。抗-CCP抗体和RF阳性患者病程均长于各自的阴性组(P<0.05),但两组患者血沉(ESR)和C-反应蛋白(CRP)等差异无统计学意义(P>0.05)。结论抗-CCP抗体和RF对诊断RA具有相似的较高敏感度和特异性。
Objective To investigate the diagnostic value of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA). Methods Serum samples of 73 patients with RA, 72 patients with non-RA and 65 healthy controls were collected randomly. RF and ELISA were used to determine the anti-CCP antibody by immunoturbidimetry. The sensitivity of RF and anti-CCP antibodies were calculated respectively , Specificity and consistency. Results The detection results of anti-CCP antibody and RF in RA group were significantly higher than those in non-RA group and healthy control group (P <0.01). The sensitivities of RF and anti-CCP antibody in diagnosing RA were 75.3% and 69.9%, respectively, and the specificity were 75.2% and 97.8% respectively. The detection rates of RA and anti-CCP antibodies were similar (P> 0.05). The duration of anti-CCP antibody and RF positive patients were longer than their negative counterparts (P <0.05). There was no significant difference in ESR and CRP between the two groups (P> 0.05). Conclusion Anti-CCP antibody and RF have similar sensitivity and specificity to diagnosing RA.