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目的 探讨急慢性肝病可溶性白介素2受体的改变,为诊断病情演变和预后判定寻找可靠的依据。 方法 健康对照(n=30)研究,采用夹心酶联免疫吸附法测定173例各型肝病患者血清IL-2受体(sIL-2R)水平,包括急性病毒性肝炎80例,慢性乙型肝炎21例,肝炎后肝硬化35例和原发性肝癌37例,并对测定结果进行分析。 结果 各组患者血清sIL-2R均明显高于对照组(P<0.01),其中急性病毒性肝炎黄疸期血清sIL-2R明显高于恢复期(P<0.01),各型急性肝炎之间血清sIL-2R无显著差异(P>0.05);急性肝炎组明显高于慢性肝炎组(P<0.01);慢性乙型肝炎ALT异常组血清sIL-2R明显高于ALT正常组(P<0.01);Child’s C级肝炎后肝硬化者明显高于CHild’B,A级者(P<0.01);原发性肝癌者血清sIL-2R水平与肿瘤体积大小有关(P<0.05)。 结论 急慢性肝病患者血清sIL-2R水平均明显增高,其水平的高低在一定程度上反映了机体免疫功能状态和肝细胞损伤的程度。
Objective To investigate the changes of soluble interleukin-2 receptor in acute and chronic liver disease and to find a reliable basis for the diagnosis of disease progression and prognosis. Methods Healthy controls (n = 30) were included in this study. Serum IL-2 receptor (sIL-2R) levels were measured in 173 patients with various liver diseases by sandwich enzyme-linked immunosorbent assay, including 80 cases of acute viral hepatitis and 21 cases of chronic hepatitis B Cases, 35 cases of posthepatitis cirrhosis and 37 cases of primary liver cancer, and analysis of the results. Results Serum sIL-2R in each group was significantly higher than that in the control group (P <0.01). Serum sIL-2R in jaundice of acute viral hepatitis was significantly higher than that in recovery (P <0.01) (P <0.05). The serum levels of sIL-2R in patients with acute hepatitis were significantly higher than those in patients with chronic hepatitis (P <0.01). The serum levels of sIL-2R in patients with chronic hepatitis B were significantly higher than those in patients with normal ALT (P <0.01) The level of serum sIL-2R in patients with primary hepatocellular carcinoma was significantly correlated with tumor size (P <0.05). Conclusions Serum levels of sIL-2R in patients with acute and chronic liver diseases are significantly increased. The level of serum sIL-2R reflects the degree of immune function and hepatocellular injury to a certain extent.