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目的 观察常温下门静脉阻断再通后对肝脏、肠道的影响 ,明确有无细菌移位及与阻断时间的关系。方法 家兔40只随机分为 4组 ,分别阻断门静脉 0min(A组 )、15min(B组 )、30min(C组 )、45min(D组 )。 6h后取肠系膜淋巴结、下腔静脉血作细菌培养 ,同时测定肝肾功能 ,并观察肝脏、空肠、回肠组织形态学变化。结果 B、C、D组肝脏、肠粘膜结构及肝功能与A组相比均有不同程度损伤。阻断 30min以上组 (C、D组 )除上述指标变化明显外 ,细菌移位率亦较A组显著增高。肾功能各组间无差异。结论 常温下门静脉阻断再通可致肝脏、肠道粘膜损伤 ,并促发细菌移位 ,其程度随阻断时间延长而加重。
Objective To observe the effects of portal vein occlusion recanalization on the liver and intestine at room temperature and to determine the relationship between the bacterial translocation and the time of occlusion. Methods Forty rabbits were randomly divided into four groups, blocking the portal vein 0min (group A), 15min (group B), 30min (group C), 45min (group D). Six hours later, mesenteric lymph nodes and inferior vena cava blood were used for bacterial culture. Liver and kidney function were also measured. Morphological changes of liver, jejunum and ileum were observed. Results The liver, intestinal mucosa structure and liver function in group B, C and D were all different degrees of injury compared with group A. Blockade more than 30min group (C, D group) in addition to the above indicators changed significantly, the bacterial translocation rate was significantly higher than the A group. No difference in renal function between the various groups. Conclusions The recanalization of portal vein at room temperature can cause liver and intestinal mucosal injury and promote bacterial translocation, which aggravates with the prolongation of blocking time.