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为了解雷公藤多甙对Ⅰ型糖尿病氧自由基和T细胞的影响以及他们的关系 ,以链脲佐菌素 (STZ)诱导的迟发性糖尿病大鼠为研究对象 ,于发病第 2天用T11灌胃后 ,连续测定外周血中T细胞亚群CD+ 2 、CD+ 4、CD+ 8、黄嘌呤氧化酶 (XOD)、超氧化物歧化酶 (SOD)、过氧化酶 (CAT)和丙二醛 (MDA)等的水平。结果显示 ,糖尿病大鼠 (DM)血清XOD、MDA与CD+ 4水平明显高于对照组 ;SOD、CAT和CD+ 8水平明显降低。服用T11后 ,上述指标于 6～ 8周分别恢复正常。DM大鼠经T11治疗后 ,外周血CD+ 4、CD+ 8T细胞亚群与 12项有关自由基的指标变化规律类似 ,说明大鼠发病时氧自由基的产生与T细胞亚群的异常分化有着密切的关系 ;T11不仅能抑制T细胞亚群的异常分化且可使氧自由基恢复正常。
In order to understand the effects of tripterygium glycosides on type 1 diabetes mellitus and T cells and the relationship between them, streptozotocin (STZ) -induced delayed-onset diabetic rats were used as research objects. On day 2 T lymphocyte subsets CD + 2, CD + 4, CD + 8, xanthine oxidase (XOD), superoxide dismutase (SOD), peroxidase (CAT) and malondialdehyde (MDA) and other levels. The results showed that the serum levels of XOD, MDA and CD + 4 in diabetic rats were significantly higher than those in the control group; the levels of SOD, CAT and CD + 8 were significantly decreased. After taking T11, the above indexes returned to normal after 6 to 8 weeks respectively. After T11 treatment, the changes of CD + 4, CD + 8 T cell subsets in peripheral blood of DM rats were similar to those of 12 related free radicals, indicating that there was a close relationship between the production of oxygen free radicals and the abnormal differentiation of T cell subsets in rats T11 can not only inhibit the abnormal differentiation of T cell subsets and make oxygen free radicals return to normal.