论文部分内容阅读
目的 进一步研究有机磷农药急性中毒患者的细胞免疫状态。方法 应用流式细胞术检测29例有机磷农药急性中毒患者治疗前后淋巴细胞4种免疫表型 ,并与正常组进行比较。 结果 有机磷农药急性中毒患者治疗前CD+3 、CD+4、CD+56 +16 细胞及CD+4/CD+8 比值明显低于正常对照组 (P<0.001或<0.05) ;治疗后CD+3 、CD+4、CD +56 +16 细胞均升高 ,与治疗前相比差异非常显著 (P<0.01或0.05) ;CD +8 细胞三组间无明显差异 (P>0.05)。 结论 急性有机磷农药中毒患者细胞免疫功能低下 ,治疗后免疫功能改善 ,检测细胞免疫功能对患者的病情判断、药物治疗及预后评估具有一定意义
Objective To further study the cellular immune status of patients with organophosphate pesticide acute poisoning. Methods Four kinds of immunophenotypes of lymphocytes in 29 patients with acute poisoning of organophosphorus pesticide before and after treatment were detected by flow cytometry and compared with the normal group. Results Before treatment, the ratio of CD + 3, CD + 4, CD + 56 + 16 cells and CD + 4 / CD + 8 in patients with organophosphate pesticide acute poisoning was significantly lower than that in the normal control group (P <0.001 or < +3, CD +4 and CD +56 +16 cells, respectively, which were significantly different from those before treatment (P <0.01 or 0.05). There was no significant difference among the three groups (P> 0.05). Conclusions Acute organophosphorus pesticide poisoning patients with low cellular immunity, improved immune function after treatment, detection of cellular immune function in patients with disease judgment, drug treatment and prognosis evaluation of a certain significance