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背景:解脲脲原体引起女性泌尿生殖道感染可导致不育不孕和自然流产,但其是否为导致胎儿畸形的因素之一尚不十分清楚。目的:探讨解脲脲原体感染是导致胎儿畸形重要因素之一。设计:以患儿及其父母为研究对象,非随机化同期对照,观察对比研究。单位:一所医学院的微生物与免疫学教研室。对象:选择1995/1997由泸州医学院微免教研室对泸州医学院第一附属医院妇产科和泸州市第一人民医院妇产科门诊及住院16例畸形胎儿(女3例,男13例)及其父母为研究对象。方法:对16例畸形胎儿脐带血,畸形儿父亲的精液和异常妊娠产妇的宫颈黏液或阴道分泌物进行解脲脲原体分离。采用大环内酯类和氨基糖甙类抗生素对11例夫妇进行治疗,然后追踪再次妊娠及生育现象。主要观察指标:脲脲原体感染与胎儿畸形的关系。结果:16例中11例解脲脲原体阳性,阳性率为69%。11例解脲脲原体阳性者抗风疹病毒、抗巨细胞病毒、抗弓形抗体和染色体均未发现异常。已追踪到的4例再次妊娠结果、妊娠过程正常,新生儿发育良好,追踪观察到2岁未发现器质性和功能性异常。结论:女性生殖道解脲脲原体感染与胎儿畸形的发生有一定关系,从而为干预胎儿畸形发生提供理论依据。
BACKGROUND: Ureaplasma urealyticum causes genitourinary tract infections in women leading to infertility and spontaneous abortion, but it is not yet clear whether one of the factors leading to fetal malformations is. Objective: To investigate the infection of Ureaplasma urealyticum is one of the important factors leading to fetal malformations. Design: The children and their parents as the research object, non-randomized contemporaneous control, observe the comparative study. Unit: Department of Microbiology and Immunology, Medical College. PARTICIPANTS: CHOICE 1995/1997 Sixteen cases of deformity fetus (3 males and 13 females) were collected from Department of Gynecology and Obstetrics, the First Affiliated Hospital of Luzhou Medical College and the First People’s Hospital of Luzhou City, And their parents as the research object. Methods: Ureaplasma urealyticum was isolated from umbilical cord blood of 16 cases of deformed fetus, sperm of father with abnormality and cervical mucus or vaginal discharge of abnormal pregnant woman. Using macrolide and aminoglycoside antibiotics, 11 couples were treated, followed by follow-up of pregnancy and fertility. MAIN OUTCOME MEASURES: Relationship between Ureaplasma urealyticum infection and fetal malformations. Results: Among the 16 cases, 11 cases were positive for Ureaplasma urealyticum, the positive rate was 69%. 11 cases of Ureaplasma urealyticum positive anti-rubella virus, anti-cytomegalovirus, anti-anti-circular antibodies and chromosome were found abnormal. Has been traced to the 4 cases of pregnancy results again, the normal pregnancy process, newborn well developed, 2-year follow-up was observed without organic and functional abnormalities. Conclusion: The female reproductive tract Ureaplasma urealyticum infection and fetal malformations have a certain relationship, and thus provide a theoretical basis for the intervention of fetal malformations.